The impact of - Chalmers Open Digital Repository
Good overview of pleiotropic effects. Statins may have good effects for Alzheimer's and Parkinson's disease, infection management, and traumatic brain injury and spinal cord injury. 2015-12-08 2002-04-01 Recent experimental evidence supports the premise that clinical benefits are related primarily to pleiotropic effects of statins (endothelial function, inflammation, coagulation and plaque vulnerability). 2021-01-28 the production by a single gene of multiple phenotypic effects. The term is often used to refer to a single gene defect that is expressed as problems in multiple systems of the body, such as in osteogenesis imperfecta, where the gene causes defects in several different systems that contain collagen. 2014-04-08 Pleiotropic effects of HIF-1 blockade on tumor radiosensitivity.
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How to use pleiotropic in a sentence. Nov 19, 2018 Statins exerts their pleiotropic effects by hindering the conversion of HMG-CoA to L-mevalonic corrosive, statins keep the union of imperative Aug 25, 2020 Multivariable Mendelian randomization estimates for effects of genetically mimicked statins (effect sizes of LDL-cholesterol) and of testosterone ( Jan 28, 2021 We also evaluated the effect of short-term GOS feeding on how the aging gut microbiome responds to antibiotic challenges, since these Official Title: A Multicenter, Randomized Double-Blind Study Comparing The Pleiotropic Effects Of Atorvastatin 10 Mg And 80 Mg Over A 26-Week Period In May 1, 2019 Pleiotropic genes are genes that affect more than one trait. For example, many genes required for pigmentation in the fruit fly Drosophila Nov 5, 2015 Selected genes may be pleiotropic, affecting multiple phenotypes and resulting in more than one disease or trait. Patterns of pleiotropy may be Though pleiotropic effects are defined as a single gene affecting multiple systems or determining more than one phenotype, lately statin pleiotropy is referred as Sep 5, 2017 Pleiotropic effects occur when a single genetic variant independently influences multiple phenotypes.
MCP produces pleiotropic effects, including but not limited to its antagonism of galectin-3, which have shown benefit in preclinical and clinical models. pleiotropic effectの意味や使い方 多面効果 - 約1173万語ある英和辞典・和英辞典。発音・イディオムも分かる英語辞書。 The Pleiotropic Effect of Physical Exercise on Mitochondrial Dynamics in Aging Skeletal Muscle Elena Barbieri , 1 Deborah Agostini , 1 Emanuela Polidori , 1 Lucia Potenza , 1 Michele Guescini , 1 Francesco Lucertini , 1 Giosuè Annibalini , 1 Laura Stocchi , 2 Mauro De Santi , 1 and Vilberto Stocchi 1 2021-04-10 · The pleiotropic effects of statins may be due to the fact that they are antibiotics.
Pleiotropic Effects of HMG-CoA Reductase Inhibitors - KI Open
MC Soares, R Mazzei, SC Cardoso, C Ramos, R Bshary. Scientific reports 9 (1), 1-10, 2019. Research has indicated that statins also possess some pleiotropic effects that are independent of the cholesterol lowering properties. It is thought that the studies (GWAS) have been associated with risks of multiple cancer sites, suggesting pleiotropic effects.
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Pleiotropic effects mediated by inhibition of isoprenoids correlate with the inhibition of cholesterol biosynthesis and are difficult to quantitate. Regulatory agencies require that new cholesterol-lowering treatments should be tested on top of background standard of care therapy, including statins. Pleiotropic effects are most commonly noticed in conjunction with genetic disorders, since a mutation on a single gene may result in multiple problems affecting growth and development, i.e., height, weight, skeletal development. If there hadn’t been a mutation on that gene, the pleiotropic impact may have gone unnoticed. Antagonistic pleiotropy is a theory proposed to explain how senescence, or biological aging, can be attributed to natural selection of certain pleiotropic alleles. In antagonistic pleiotropy, an allele that has a negative impact on an organism can be favored by natural selection if the allele also produces advantageous effects.
2017 — Lipids Health Dis. 15, 118 (2016).
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Circ Res. SS, Blumenthal RS. Non-cardiovascular effects associated with statins. 10 nov.
An example of this is testosterone levels in male humans. Recent experimental evidence supports the premise that clinical benefits are related primarily to pleiotropic effects of statins (endothelial function, inflammation, coagulation and plaque vulnerability).
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Cholesterol Cholesterol is an essential component of cell membranes and is the immediate precursor of steroid hormones and bile acids. The rate-limiting enzyme in cholesterol biosynthesis in the liver is HMG-CoA reductase. 3. Thus, it is not surprising that mutations in genes which function in melanocyte development or melanogenesis frequently cause pleiotropic effects involving sight, hearing and neurologic functioning.